Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P09038
UPID:
FGF2_HUMAN
Alternative names:
Basic fibroblast growth factor; Heparin-binding growth factor 2
Alternative UPACC:
P09038; A4LBB8; O00527; P78443; Q16443; Q5PY50; Q7KZ11; Q7KZ72; Q9UC54; Q9UCS5; Q9UCS6
Background:
Fibroblast growth factor 2 (FGF2), also known as basic fibroblast growth factor and heparin-binding growth factor 2, is a multifunctional protein with a pivotal role in various biological processes. It serves as a ligand for FGFR1-4, facilitating FGF2 signaling through integrin ITGAV:ITGB3 interaction. FGF2 is instrumental in cell survival, division, differentiation, and migration, showcasing its potency as a mitogen and its capability to induce angiogenesis. Additionally, it mediates ERK1/2 phosphorylation, promoting retinal lens fiber differentiation.
Therapeutic significance:
Understanding the role of Fibroblast growth factor 2 could open doors to potential therapeutic strategies.