Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P09923
UPID:
PPBI_HUMAN
Alternative names:
-
Alternative UPACC:
P09923; B2R7Y4; Q53S80; Q9UBV5; Q9UCL2
Background:
Intestinal-type alkaline phosphatase, encoded by the gene with the accession number P09923, plays a crucial role in the human body by hydrolyzing various phosphate compounds. This enzyme is pivotal in maintaining the balance of phosphate levels within the body, facilitating the digestion process, and contributing to the overall metabolic functions.
Therapeutic significance:
Understanding the role of Intestinal-type alkaline phosphatase could open doors to potential therapeutic strategies. Its ability to regulate phosphate levels suggests its importance in metabolic health and offers a promising avenue for exploring treatments for related disorders.