Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P13612
UPID:
ITA4_HUMAN
Alternative names:
CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha
Alternative UPACC:
P13612; D3DPG4; Q7Z4L6
Background:
Integrin alpha-4, known as CD49 antigen-like family member D or VLA-4 subunit alpha, plays a pivotal role in cell adhesion and signaling. It binds to fibronectin, VCAM1, and MADCAM1, facilitating leukocyte endothelial transmigration. This protein's interaction with fractalkine enhances ligand binding, indicating its complex role in cellular communication and immune response.
Therapeutic significance:
Understanding the role of Integrin alpha-4 could open doors to potential therapeutic strategies. Its involvement in cell adhesion and immune response highlights its potential as a target for modulating inflammatory diseases and immune-related disorders.