Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P13928
UPID:
ANXA8_HUMAN
Alternative names:
Annexin VIII; Annexin-8; Vascular anticoagulant-beta
Alternative UPACC:
P13928; A6NDE6; A6NLM1; B4DKI1; B4DTC9; Q5T2P8; Q5VTM4; Q6GMY3; Q9BT34
Background:
Annexin A8, also known as Annexin VIII, Annexin-8, and Vascular anticoagulant-beta, plays a pivotal role in the regulation of blood coagulation. This protein functions as an anticoagulant by indirectly inhibiting the thromboplastin-specific complex within the blood coagulation cascade.
Therapeutic significance:
Understanding the role of Annexin A8 could open doors to potential therapeutic strategies. Its involvement in blood coagulation positions it as a key target for developing treatments for coagulation disorders.