Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P16591
UPID:
FER_HUMAN
Alternative names:
Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer
Alternative UPACC:
P16591; B2RCR4; B4DSQ2; H2FLB8
Background:
Tyrosine-protein kinase Fer, known by alternative names such as Feline encephalitis virus-related kinase FER and Proto-oncogene c-Fer, plays a pivotal role in cellular processes including actin cytoskeleton regulation, cell adhesion, migration, and chemotaxis. It functions downstream of receptors like EGFR and PDGFRB, influencing cell proliferation, mitotic cycle regulation, and insulin signaling. Additionally, it contributes to synaptic organization and neuron-neuron transmission, highlighting its importance in neuronal health.
Therapeutic significance:
Understanding the role of Tyrosine-protein kinase Fer could open doors to potential therapeutic strategies.