Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P20340
UPID:
RAB6A_HUMAN
Alternative names:
-
Alternative UPACC:
P20340; A8K133; B7Z772; F5H668; Q1W5D8; Q5U0A8; Q9UBE4
Background:
Ras-related protein Rab-6A plays a pivotal role in cellular transport mechanisms, specifically regulating COPI-independent retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Its activity includes a low GTPase function and the recruitment of VPS13B to the Golgi membrane, essential for maintaining cellular homeostasis and proper protein sorting. Additionally, Rab-6A is implicated in neuron projection development, highlighting its significance in neural function.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-6A could open doors to potential therapeutic strategies. Its involvement in critical transport pathways and neuron development positions it as a key target for addressing cellular dysfunction and diseases related to protein mislocalization.