Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P20809
UPID:
IL11_HUMAN
Alternative names:
Adipogenesis inhibitory factor
Alternative UPACC:
P20809; B4DQV5; Q96EB4
Background:
Interleukin-11, also known as Adipogenesis inhibitory factor, plays a crucial role in hematopoiesis by stimulating the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. It also induces megakaryocyte maturation, leading to increased platelet production. Beyond hematopoiesis, IL-11 promotes hepatocyte proliferation in response to liver damage, engaging in liver regeneration processes.
Therapeutic significance:
Understanding the role of Interleukin-11 could open doors to potential therapeutic strategies. Its ability to stimulate cell proliferation and tissue regeneration highlights its potential in treating hematopoietic disorders and liver injuries, making it a target of interest in regenerative medicine and drug discovery.