Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P21246
UPID:
PTN_HUMAN
Alternative names:
Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; Osteoblast-specific factor 1
Alternative UPACC:
P21246; Q5U0B0; Q6ICQ5; Q9UCC6
Background:
Pleiotrophin, a multifunctional secreted growth factor, is known by various names including Heparin-binding brain mitogen and Osteoblast-specific factor 1. It plays a pivotal role in regulating cell processes such as proliferation, survival, differentiation, and migration across several tissues, notably in neurons and bones. Its interaction with cell-surface receptors and proteoglycans mediates critical signaling pathways, including the PI3K-AKT and MAPK pathways, essential for cellular and tissue homeostasis.
Therapeutic significance:
Understanding the role of Pleiotrophin could open doors to potential therapeutic strategies. Its involvement in key biological processes and signaling pathways highlights its potential as a target for therapeutic intervention in diseases where these pathways are dysregulated.