Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P22301
UPID:
IL10_HUMAN
Alternative names:
Cytokine synthesis inhibitory factor
Alternative UPACC:
P22301
Background:
Interleukin-10 (IL-10), also known as Cytokine Synthesis Inhibitory Factor, plays a pivotal role in the immune system. It acts on various cells, showcasing profound anti-inflammatory functions by binding to its receptor, leading to a cascade of intracellular events that culminate in the suppression of pro-inflammatory cytokines and inhibition of antigen-presenting cells. This process is crucial for maintaining immune homeostasis and preventing excessive tissue damage during inflammation.
Therapeutic significance:
Understanding the role of Interleukin-10 could open doors to potential therapeutic strategies. Its ability to modulate the immune response and maintain tissue integrity by controlling inflammation positions IL-10 as a promising target for the development of treatments for inflammatory and autoimmune diseases.