Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P25445
UPID:
TNR6_HUMAN
Alternative names:
Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor
Alternative UPACC:
P25445; A9UJX4; B6VNV4; Q14292; Q14293; Q14294; Q14295; Q16652; Q5T9P1; Q5T9P2; Q5T9P3; Q6SSE9
Background:
Tumor necrosis factor receptor superfamily member 6, also known as FAS, plays a pivotal role in regulating programmed cell death and maintaining immune system homeostasis. It acts as a receptor for TNFSF6/FASLG, initiating apoptosis through the recruitment of FADD and caspase-8. This process is crucial for peripheral tolerance and the antigen-stimulated suicide of mature T-cells.
Therapeutic significance:
Autoimmune lymphoproliferative syndrome 1A, a disorder linked to FAS gene variants, highlights the protein's critical role in immune regulation. Understanding FAS's mechanisms offers a pathway to novel treatments for autoimmune diseases and immune system disorders.