Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P29692
UPID:
EF1D_HUMAN
Alternative names:
Antigen NY-CO-4
Alternative UPACC:
P29692; B4DDU4; D3DWK3; E9PBQ9; Q4VBZ6; Q969J1; Q96I38
Background:
Elongation factor 1-delta (EF-1-delta), also known as Antigen NY-CO-4, plays a crucial role in protein synthesis. It facilitates the exchange of GDP for GTP, rejuvenating EF-1-alpha for aminoacyl-tRNAs transfer to the ribosome. Additionally, EF-1-delta is pivotal in regulating the heat-shock response, associating with transcription factors and binding directly to heat shock promoter elements.
Therapeutic significance:
Understanding the role of Elongation factor 1-delta could open doors to potential therapeutic strategies. Its involvement in protein synthesis and stress response regulation highlights its importance in cellular functions and disease mechanisms.