Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P32881
UPID:
IFNA8_HUMAN
Alternative names:
Interferon alpha-B; Interferon alpha-B2
Alternative UPACC:
P32881; P01565; P09236; Q5VWV7; Q5VYQ3
Background:
Interferon alpha-8, also known as Interferon alpha-B or Interferon alpha-B2, is a pivotal protein produced by macrophages. It plays a crucial role in the body's antiviral defense mechanisms. Specifically, Interferon alpha-8 stimulates the production of two key enzymes: a protein kinase and an oligoadenylate synthetase, both of which are instrumental in inhibiting viral replication.
Therapeutic significance:
Understanding the role of Interferon alpha-8 could open doors to potential therapeutic strategies. Its antiviral activities make it a significant target for research, aiming to harness its properties to combat viral infections effectively.