Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P40198
UPID:
CEAM3_HUMAN
Alternative names:
Carcinoembryonic antigen CGM1
Alternative UPACC:
P40198; G5E978; Q3KPH9
Background:
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3), also known as Carcinoembryonic antigen CGM1, plays a pivotal role in the innate immune system. It acts as a major granulocyte receptor, facilitating the recognition and opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neisseria, Moraxella, and Haemophilus species. This process is crucial for the efficient clearance of pathogens.
Therapeutic significance:
Understanding the role of Carcinoembryonic antigen-related cell adhesion molecule 3 could open doors to potential therapeutic strategies. Its involvement in pathogen clearance highlights its significance in combating infectious diseases and underscores the potential for targeted interventions to enhance immune response.