Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P40933
UPID:
IL15_HUMAN
Alternative names:
-
Alternative UPACC:
P40933; D3DNZ2; O00440; O43512; Q495Z8; Q6FGX7; Q93058; Q9UBA3
Background:
Interleukin-15 (IL-15) is a pivotal cytokine in immune regulation, influencing both innate and adaptive immunity. It enhances the proliferation of natural killer cells, T-cells, and B-cells, and modulates the secretion of various cytokines. IL-15 operates uniquely, being presented on the surface of producing cells, facilitating direct signaling to cells bearing the appropriate receptors, which activates pathways including JAK/STAT phosphorylation.
Therapeutic significance:
Understanding the role of Interleukin-15 could open doors to potential therapeutic strategies. Its ability to modulate immune responses positions it as a key target for interventions in diseases where the immune system plays a critical role.