Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P42694
UPID:
HELZ_HUMAN
Alternative names:
Down-regulated in human cancers protein
Alternative UPACC:
P42694; I6L9H4
Background:
The Probable helicase with zinc finger domain, also known as Down-regulated in human cancers protein, is implicated in RNA metabolism across various tissues and organs during embryonic development. Its potential helicase activity suggests a critical role in the processing and modification of RNA, essential for proper cellular function and organismal development.
Therapeutic significance:
Understanding the role of Probable helicase with zinc finger domain could open doors to potential therapeutic strategies. Its involvement in RNA metabolism positions it as a key player in cellular processes, offering a promising target for drug discovery efforts aimed at addressing developmental disorders and possibly cancer.