Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P53384
UPID:
NUBP1_HUMAN
Alternative names:
Nucleotide-binding protein 1
Alternative UPACC:
P53384; Q32M30; Q498A9; Q53FS7
Background:
Cytosolic Fe-S cluster assembly factor NUBP1 plays a crucial role in the cytosolic iron-sulfur (Fe/S) protein assembly machinery. It is essential for the maturation of extramitochondrial Fe-S proteins, forming a heterotetramer with NUBP2 to mediate Fe-S cluster assembly and transfer. Additionally, NUBP1 is involved in centrosome duplication regulation and negatively impacts cilium formation and structure.
Therapeutic significance:
Understanding the role of Cytosolic Fe-S cluster assembly factor NUBP1 could open doors to potential therapeutic strategies.