Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P55268
UPID:
LAMB2_HUMAN
Alternative names:
Laminin B1s chain; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta
Alternative UPACC:
P55268; Q16321
Background:
Laminin subunit beta-2, known by alternative names such as Laminin B1s chain and Laminin-11 subunit beta, plays a crucial role in the architecture of basement membranes. It is pivotal in mediating cell attachment, migration, and organization during embryonic development by interacting with other extracellular matrix components.
Therapeutic significance:
Laminin subunit beta-2 is implicated in severe disorders like Pierson syndrome and Nephrotic syndrome 5, characterized by early-onset nephrotic syndrome and potential neurodevelopmental delay. Understanding the role of Laminin subunit beta-2 could open doors to potential therapeutic strategies for these life-threatening conditions.