Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P57768
UPID:
SNX16_HUMAN
Alternative names:
-
Alternative UPACC:
P57768; A8K4D8; Q658L0; Q8N4U3
Background:
Sorting nexin-16 (SNX16) is a pivotal protein implicated in the regulation of intracellular trafficking. It facilitates the transport of proteins from early to late endosomes and to the lysosome, ensuring the degradation of EGFR post-EGF signaling. Additionally, SNX16 plays a crucial role in the intracellular transport of vesicular stomatitis virus nucleocapsids, moving them from the endosome to the cytoplasm.
Therapeutic significance:
Understanding the role of Sorting nexin-16 could open doors to potential therapeutic strategies. Its involvement in intracellular protein transport and virus nucleocapsid movement highlights its potential as a target in treating diseases related to endosomal transport dysfunction and viral infections.