Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P98066
UPID:
TSG6_HUMAN
Alternative names:
Hyaluronate-binding protein; TNF-stimulated gene 6 protein; Tumor necrosis factor alpha-induced protein 6
Alternative UPACC:
P98066; Q53TI7; Q8WWI9
Background:
The Tumor necrosis factor-inducible gene 6 protein, also known as Hyaluronate-binding protein or TNF-stimulated gene 6 protein, plays a pivotal role in extracellular matrix organization and tissue remodeling. It is crucial in the transfer and modification of heavy chains in the inter-alpha-inhibitor complex to hyaluronan, influencing antiprotease functions, oocyte fertilization, and leukocyte rolling. Its ability to modulate chemokine interactions and limit neutrophil recruitment highlights its regulatory role in inflammation.
Therapeutic significance:
Understanding the role of Tumor necrosis factor-inducible gene 6 protein could open doors to potential therapeutic strategies. Its involvement in key physiological processes such as tissue remodeling, inflammation regulation, and bone remodeling positions it as a target for therapeutic intervention in related disorders.