Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q04756
UPID:
HGFA_HUMAN
Alternative names:
-
Alternative UPACC:
Q04756; Q14726; Q2M1W7; Q53X47
Background:
The Hepatocyte growth factor activator, identified by the unique identifier Q04756, plays a pivotal role in cellular processes by activating hepatocyte growth factor (HGF). This activation involves the conversion of HGF from a single chain to a heterodimeric form, a critical step in initiating various biological responses.
Therapeutic significance:
Understanding the role of Hepatocyte growth factor activator could open doors to potential therapeutic strategies. Its crucial function in activating HGF suggests its involvement in key physiological processes, making it a target of interest for drug discovery efforts aimed at modulating cellular growth and repair mechanisms.