Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q3KNT9
UPID:
TMM95_HUMAN
Alternative names:
Transmembrane protein 95
Alternative UPACC:
Q3KNT9; B7WPI7; Q6UXT3; Q8IW68
Background:
The Sperm-egg fusion protein TMEM95, also known as Transmembrane protein 95, plays a crucial role in reproductive biology. It is essential for the fusion of sperm with the egg membrane during fertilization, a key step in the conception process. This protein's unique function highlights its importance in the successful union of gametes, leading to embryo development.
Therapeutic significance:
Understanding the role of Sperm-egg fusion protein TMEM95 could open doors to potential therapeutic strategies. Its pivotal role in fertilization makes it a target for studies aimed at addressing infertility issues. By exploring the mechanisms of TMEM95, researchers can develop interventions to assist those facing challenges in conceiving, thereby contributing to the field of reproductive health.