Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q5VYY2
UPID:
LIPM_HUMAN
Alternative names:
Lipase-like abhydrolase domain-containing protein 3
Alternative UPACC:
Q5VYY2; A6PVS3; B2RXK7; B5MCR3
Background:
Lipase member M, also known as Lipase-like abhydrolase domain-containing protein 3, plays a pivotal role in the final step of keratinocyte differentiation. Its unique function in lipid metabolism within the most differentiated epidermal layers underscores its importance in skin health.
Therapeutic significance:
Understanding the role of Lipase member M could open doors to potential therapeutic strategies. Its critical function in skin differentiation and lipid metabolism highlights its potential as a target for treating skin disorders.