Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q5VZV1
UPID:
MT21C_HUMAN
Alternative names:
Methyltransferase-like protein 21C
Alternative UPACC:
Q5VZV1
Background:
Protein-lysine methyltransferase METTL21C, also known as Methyltransferase-like protein 21C, plays a crucial role in the post-translational modification of proteins. This enzyme specifically targets lysine residues, adding methyl groups to alter protein function and interactions. Its precise mechanism and the full spectrum of substrates remain areas of active research, highlighting its potential in cellular regulation and signaling pathways.
Therapeutic significance:
Understanding the role of Protein-lysine methyltransferase METTL21C could open doors to potential therapeutic strategies. Its involvement in key biological processes suggests that modulation of its activity could have implications for treating diseases where protein methylation plays a critical role.