Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q6GMR7
UPID:
FAAH2_HUMAN
Alternative names:
Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2
Alternative UPACC:
Q6GMR7; Q86VT2; Q96N98
Background:
Fatty-acid amide hydrolase 2, also known as Anandamide amidohydrolase 2 and Oleamide hydrolase 2, plays a crucial role in the hydrolysis of endogenous amidated lipids. These include sleep-inducing oleamide, the endocannabinoid anandamide, and other fatty amides, converting them into their corresponding fatty acids. This process is vital for regulating the signaling functions of these molecules, with a preference for monounsaturated substrates like anandamide.
Therapeutic significance:
Understanding the role of Fatty-acid amide hydrolase 2 could open doors to potential therapeutic strategies. Its involvement in the metabolism of bioactive lipid molecules positions it as a key target for modulating physiological processes related to sleep, pain, and inflammation.