Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q6ZRF8
UPID:
RN207_HUMAN
Alternative names:
-
Alternative UPACC:
Q6ZRF8; A2VCM8; B4DFR6; Q5TGS6; Q6ZS63; Q96MP2
Background:
RING finger protein 207 plays a crucial role in cardiac repolarization, potentially through stabilizing the membrane expression of the potassium channel KCNH2/HERG. It may also assist in the synthesis, folding, or export of this channel from the endoplasmic reticulum, facilitated by heat shock proteins.
Therapeutic significance:
Understanding the role of RING finger protein 207 could open doors to potential therapeutic strategies, especially in the context of cardiac health and diseases related to cardiac repolarization.