Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86YS3
UPID:
RFIP4_HUMAN
Alternative names:
Arfophilin-2
Alternative UPACC:
Q86YS3; Q52LI1; Q8N829; Q8NDT7; Q969D8
Background:
Rab11 family-interacting protein 4, also known as Arfophilin-2, plays a crucial role in endocytic traffic regulation and membrane delivery. It is essential for cytokinesis, acting as an 'address tag' for recycling endosome membranes to the cleavage furrow. Additionally, it may facilitate the egress of HCMV out of the nucleus, independent of ARF6.
Therapeutic significance:
Understanding the role of Rab11 family-interacting protein 4 could open doors to potential therapeutic strategies.