Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8HWS3
UPID:
RFX6_HUMAN
Alternative names:
Regulatory factor X 6; Regulatory factor X domain-containing protein 1
Alternative UPACC:
Q8HWS3; Q5T6B3
Background:
DNA-binding protein RFX6, also known as Regulatory factor X 6, plays a pivotal role in endocrine pancreas development. It is essential for the differentiation of islet cells and insulin production, acting downstream of NEUROG3. RFX6 activates transcription by partnering with RFX3, targeting genes crucial for beta-cell maturation and function.
Therapeutic significance:
RFX6's involvement in Mitchell-Riley syndrome, a disorder marked by neonatal diabetes and pancreatic anomalies, underscores its therapeutic potential. Understanding RFX6's role could open doors to innovative treatments for pancreatic disorders and diabetes.