Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8IW03
UPID:
SIAH3_HUMAN
Alternative names:
-
Alternative UPACC:
Q8IW03; B7ZBP0; Q8N8M6
Background:
Seven in absentia homolog 3 (SIAH3) plays a crucial role in cellular homeostasis by acting as a negative regulator of PRKN translocation to damaged mitochondria. It achieves this by destabilizing PINK1 protein, which is essential for PRKN targeting to dysfunctional depolarized mitochondria. This regulatory mechanism is vital for maintaining mitochondrial integrity and function.
Therapeutic significance:
Understanding the role of Seven in absentia homolog 3 could open doors to potential therapeutic strategies. Its involvement in the regulation of mitochondrial quality control positions it as a key target for interventions in diseases characterized by mitochondrial dysfunction.