Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IYM2
UPID:
SLN12_HUMAN
Alternative names:
Schlafen family member 12
Alternative UPACC:
Q8IYM2; A8K711; Q9NP47
Background:
Ribonuclease SLFN12, also known as Schlafen family member 12, plays a pivotal role in an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. This pathway, activated by the stabilization of the PDE3A/SLFN12 complex and subsequent dephosphorylation of SLFN12, is crucial for its ribosomal RNA/rRNA ribonuclease activity, particularly in tissues with high E2 concentrations.
Therapeutic significance:
Understanding the role of Ribonuclease SLFN12 could open doors to potential therapeutic strategies, especially considering its involvement in apoptosis and cell differentiation.