Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NDG6
UPID:
TDRD9_HUMAN
Alternative names:
Tudor domain-containing protein 9
Alternative UPACC:
Q8NDG6; A1A4S7; Q6ZU54; Q8N7T3; Q8N827; Q8N9V5; Q96AS9
Background:
ATP-dependent RNA helicase TDRD9, also known as Tudor domain-containing protein 9, plays a pivotal role in spermatogenesis. It is essential for repressing transposable elements to maintain germline integrity, acting through the piRNA metabolic process. This process is crucial for the methylation and repression of transposons, with TDRD9 acting as a nuclear effector alongside PIWIL4.
Therapeutic significance:
Spermatogenic failure 30, an autosomal recessive infertility disorder linked to TDRD9, highlights the protein's critical role in human health. Understanding TDRD9's function could pave the way for innovative treatments for infertility disorders.