Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NDV3
UPID:
SMC1B_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NDV3; A0AV46; B0QY23; B0QY24; Q5TIC3; Q6ZUF9; Q9Y3G5
Background:
Structural maintenance of chromosomes protein 1B plays a pivotal role in meiosis, particularly in the cohesion of sister chromatids, axial element formation, and chromatin loop organization. It is essential for synapsis, recombination, and chromosome movements, marking its significance in genetic stability and cell division.
Therapeutic significance:
Understanding the role of Structural maintenance of chromosomes protein 1B could open doors to potential therapeutic strategies.