Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NEC5
UPID:
CTSR1_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NEC5; Q96P76
Background:
Cation channel sperm-associated protein 1 plays a pivotal role in calcium-dependent physiological responses crucial for fertilization, including sperm hyperactivation, acrosome reaction, and chemotaxis towards the oocyte. This protein's functionality underscores its importance in the reproductive process.
Therapeutic significance:
Linked to Spermatogenic failure 7, a disorder characterized by impaired sperm motility and structure, understanding the role of Cation channel sperm-associated protein 1 could open doors to potential therapeutic strategies aimed at alleviating infertility.