Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NFU1
UPID:
BEST2_HUMAN
Alternative names:
Vitelliform macular dystrophy 2-like protein 1
Alternative UPACC:
Q8NFU1; Q53YQ8; Q9NXP0
Background:
Bestrophin-2, also known as Vitelliform macular dystrophy 2-like protein 1, plays a crucial role in cellular processes by forming calcium-sensitive chloride channels that are permeable to bicarbonate. This functionality is essential for maintaining the ionic balance and proper cell signaling, highlighting its significance in cellular physiology.
Therapeutic significance:
Understanding the role of Bestrophin-2 could open doors to potential therapeutic strategies. Its involvement in critical cellular functions underscores the importance of further research to explore its therapeutic potential and address unmet medical needs.