Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q969T3
UPID:
SNX21_HUMAN
Alternative names:
Sorting nexin L
Alternative UPACC:
Q969T3; Q5JZH5; Q5JZH6; Q5JZH7; Q8WUR6; Q9BR16
Background:
Sorting nexin-21, also known as Sorting nexin L, plays a crucial role in cellular processes by binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. This protein is pivotal in intracellular trafficking, influencing the transport and sorting of various cellular components.
Therapeutic significance:
Understanding the role of Sorting nexin-21 could open doors to potential therapeutic strategies. Its involvement in intracellular trafficking suggests its potential impact on diseases related to cellular transport mechanisms.