Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q969W0
UPID:
SPTSA_HUMAN
Alternative names:
Small subunit of serine palmitoyltransferase A
Alternative UPACC:
Q969W0; B2RD54; D3DS93; Q8WTZ7
Background:
Serine palmitoyltransferase small subunit A, also known as the small subunit of serine palmitoyltransferase A, plays a crucial role in lipid metabolism. It stimulates the activity of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis. This protein's interaction with different SPTLC subunits influences substrate specificity, affecting cellular lipid composition and function.
Therapeutic significance:
Understanding the role of Serine palmitoyltransferase small subunit A could open doors to potential therapeutic strategies. Its involvement in lipid metabolism and membrane composition suggests its potential impact on diseases related to lipid dysregulation.