Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q969X5
UPID:
ERGI1_HUMAN
Alternative names:
ER-Golgi intermediate compartment 32 kDa protein
Alternative UPACC:
Q969X5; Q9H0L0; Q9H2J2; Q9ULN9
Background:
The Endoplasmic reticulum-Golgi intermediate compartment protein 1, also known as ER-Golgi intermediate compartment 32 kDa protein, plays a crucial role in cellular transport mechanisms, specifically facilitating transport between the endoplasmic reticulum and Golgi apparatus. This protein's function is vital for maintaining cellular homeostasis and ensuring the proper processing and trafficking of proteins.
Therapeutic significance:
Linked to Arthrogryposis multiplex congenita 2, neurogenic type (AMC2), a condition characterized by multiple joint contractures and muscle wasting, this protein's study offers insights into neurogenic defects. Understanding the role of Endoplasmic reticulum-Golgi intermediate compartment protein 1 could open doors to potential therapeutic strategies for AMC2, highlighting its significance in neurogenic disease research.