Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96AH8
UPID:
RAB7B_HUMAN
Alternative names:
-
Alternative UPACC:
Q96AH8
Background:
Ras-related protein Rab-7b plays a pivotal role in vesicular trafficking, guiding vesicles from endosomes to the trans-Golgi network. It serves as a crucial negative regulator of TLR9 and TLR4 signaling pathways in macrophages, facilitating lysosomal degradation of these receptors. Furthermore, it enhances megakaryocytic differentiation through a mechanism involving NF-kappa-B-dependent IL6 production, which in turn promotes the association of STAT3 with GATA1.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-7b could open doors to potential therapeutic strategies.