Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96BX8
UPID:
MOB3A_HUMAN
Alternative names:
MOB-LAK; Mob1 homolog 2A; Mps one binder kinase activator-like 2A
Alternative UPACC:
Q96BX8; B3KTF1; O75249; Q8TF69
Background:
MOB kinase activator 3A, known by alternative names such as MOB-LAK, Mob1 homolog 2A, and Mps one binder kinase activator-like 2A, plays a crucial role in cellular processes by potentially regulating the activity of kinases. This protein, identified by the accession number Q96BX8, is a pivotal component in the signaling pathways that govern cell proliferation, differentiation, and survival.
Therapeutic significance:
Understanding the role of MOB kinase activator 3A could open doors to potential therapeutic strategies. Its involvement in kinase regulation suggests a significant impact on cellular functions, making it a promising target for drug discovery efforts aimed at treating diseases through modulation of kinase activity.