Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96CW9
UPID:
NTNG2_HUMAN
Alternative names:
Laminet-2
Alternative UPACC:
Q96CW9; Q5JUJ2; Q6UXY0; Q96JH0
Background:
Netrin-G2, also known as Laminet-2, plays a crucial role in the nervous system's development. It is pivotal in controlling patterning and neuronal circuit formation at various levels, including laminar, cellular, subcellular, and synaptic. Netrin-G2 promotes neurite outgrowth of both axons and dendrites, essential for proper neuronal function.
Therapeutic significance:
Netrin-G2's involvement in a neurodevelopmental disorder characterized by severe intellectual and motor development impairments, behavioral abnormalities, and hypotonia highlights its therapeutic potential. Understanding the role of Netrin-G2 could open doors to potential therapeutic strategies for treating such complex neurological conditions.