Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96LD8
UPID:
SENP8_HUMAN
Alternative names:
Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8
Alternative UPACC:
Q96LD8; Q96QA4
Background:
Sentrin-specific protease 8, also known as Deneddylase-1, NEDD8-specific protease 1, Protease, cysteine 2, and Sentrin/SUMO-specific protease SENP8, plays a pivotal role in the NEDD8 pathway. It is responsible for the processing of full-length NEDD8 to its mature form and the deconjugation of NEDD8 from targeted proteins such as cullins or p53, which are crucial for cellular function and stability.
Therapeutic significance:
Understanding the role of Sentrin-specific protease 8 could open doors to potential therapeutic strategies. Its critical function in protein regulation and cell cycle control highlights its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.