Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96QE5
UPID:
TEFM_HUMAN
Alternative names:
-
Alternative UPACC:
Q96QE5; E1P655; Q6GPG5; Q6PJ19; Q96H04; Q9H5Z9
Background:
The Transcription elongation factor, mitochondrial, identified by the accession number Q96QE5, plays a pivotal role in enhancing the processivity of mitochondrial RNA polymerase. It is crucial for the transcription of the mitochondrial genome, including genes vital for the oxidative phosphorylation machinery, which is essential for energy production in cells.
Therapeutic significance:
Understanding the role of the Transcription elongation factor, mitochondrial, could open doors to potential therapeutic strategies. Its involvement in the regulation of mitochondrial gene transcription underscores its importance in cellular energy metabolism, presenting a promising target for therapeutic intervention.