Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q99958
UPID:
FOXC2_HUMAN
Alternative names:
Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; Transcription factor FKH-14
Alternative UPACC:
Q99958; C6KMR9; Q14DA6
Background:
Forkhead box protein C2, known by its aliases Forkhead-related protein FKHL14, Mesenchyme fork head protein 1, and Transcription factor FKH-14, plays a pivotal role in cellular processes as a transcriptional activator. Its involvement in the formation of special mesenchymal tissues underscores its significance in developmental biology.
Therapeutic significance:
The protein's link to Lymphedema-distichiasis syndrome, a genetic disorder marked by limb lymphedema and double rows of eyelashes, highlights its clinical relevance. Understanding the role of Forkhead box protein C2 could open doors to potential therapeutic strategies for this syndrome.