Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BV35
UPID:
SCMC3_HUMAN
Alternative names:
Mitochondrial ATP-Mg/Pi carrier protein 2; Short calcium-binding mitochondrial carrier protein 3; Solute carrier family 25 member 23
Alternative UPACC:
Q9BV35; B4DGB6; Q4LBC2; Q705K3; Q86Y43; Q8N2N4; Q96NQ4
Background:
The Mitochondrial adenyl nucleotide antiporter SLC25A23, also known as Mitochondrial ATP-Mg/Pi carrier protein 2 and Short calcium-binding mitochondrial carrier protein 3, plays a crucial role in cellular energy management. It facilitates the transport of adenine nucleotides across the inner mitochondrial membrane, balancing the mitochondrial matrix adenine nucleotide pool in response to cellular energetic demands. This protein also regulates mitochondrial calcium uptake and may transport divalent metal cations in complex with ATP.
Therapeutic significance:
Understanding the role of Mitochondrial adenyl nucleotide antiporter SLC25A23 could open doors to potential therapeutic strategies.