Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H2G2
UPID:
SLK_HUMAN
Alternative names:
CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; Serine/threonine-protein kinase 2
Alternative UPACC:
Q9H2G2; D3DRA0; D3DRA1; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9NQL0; Q9NQL1
Background:
The STE20-like serine/threonine-protein kinase, also known as CTCL tumor antigen se20-9, STE20-related serine/threonine-protein kinase, and Serine/threonine-protein kinase 2, plays a crucial role in mediating apoptosis and the dissolution of actin stress fibers. This protein's unique functions highlight its importance in cellular processes and signal transduction pathways.
Therapeutic significance:
Understanding the role of STE20-like serine/threonine-protein kinase could open doors to potential therapeutic strategies. Its involvement in apoptosis and actin stress fiber dissolution positions it as a key target for drug discovery efforts aimed at regulating cell death and cytoskeletal organization.