Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H492
UPID:
MLP3A_HUMAN
Alternative names:
Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; Microtubule-associated protein 1 light chain 3 alpha
Alternative UPACC:
Q9H492; E1P5P4; E1P5P5; Q9BXW5
Background:
Microtubule-associated proteins 1A/1B light chain 3A, also known as Autophagy-related protein LC3 A, plays a pivotal role in autophagy, facilitating the formation of autophagosomal vacuoles. This protein is crucial for the elongation of the phagophore membrane and, through its interaction with TEX264, aids in the endoplasmic reticulum turnover by remodeling its subdomains into autophagosomes, which then merge with lysosomes.
Therapeutic significance:
Understanding the role of Microtubule-associated proteins 1A/1B light chain 3A could open doors to potential therapeutic strategies.