Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9HBE5
UPID:
IL21R_HUMAN
Alternative names:
Novel interleukin receptor
Alternative UPACC:
Q9HBE5; A8K9E8; D3DWF7; Q96HZ1; Q9HB91
Background:
The Interleukin-21 receptor, also known as a Novel interleukin receptor, plays a pivotal role as a receptor for interleukin-21. This protein is integral to the communication pathways within the immune system, facilitating critical responses to infection and disease.
Therapeutic significance:
Linked to Immunodeficiency 56, a condition characterized by B- and T-cell defects, the Interleukin-21 receptor's dysfunction highlights its potential as a target for therapeutic intervention. Understanding the role of Interleukin-21 receptor could open doors to potential therapeutic strategies.