Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9HBM6
UPID:
TAF9B_HUMAN
Alternative names:
Neuronal cell death-related protein 7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31L
Alternative UPACC:
Q9HBM6; B2RUZ9; Q9Y2S3
Background:
Transcription initiation factor TFIID subunit 9B, also known as Neuronal cell death-related protein 7 and Transcription-associated factor TAFII31L, plays a pivotal role in cell viability. It is involved in both transcriptional activation and repression of distinct yet overlapping gene sets, potentially influencing apoptosis. As a component of several key transcriptional complexes, including TFIID and TFTC, its function is crucial for RNA polymerase II-mediated transcription.
Therapeutic significance:
Understanding the role of Transcription initiation factor TFIID subunit 9B could open doors to potential therapeutic strategies.