Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9HC97
UPID:
GPR35_HUMAN
Alternative names:
Kynurenic acid receptor
Alternative UPACC:
Q9HC97; J3KR30; O43495; Q17R58; Q4VBN5; Q4ZFV2; Q6FHI8; Q86UH4
Background:
The G-protein coupled receptor 35 (GPR35), also known as the Kynurenic acid receptor, plays a pivotal role in the tryptophan metabolic pathway. It acts as a receptor for kynurenic acid, engaging G-proteins that trigger calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Therapeutic significance:
Understanding the role of G-protein coupled receptor 35 could open doors to potential therapeutic strategies. Its involvement in the tryptophan metabolic pathway suggests a significant impact on cellular signaling and physiological processes.