Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9HCJ6
UPID:
VAT1L_HUMAN
Alternative names:
-
Alternative UPACC:
Q9HCJ6; Q8IYW8
Background:
The Synaptic vesicle membrane protein VAT-1 homolog-like plays a crucial role in the synaptic vesicle function, facilitating neurotransmitter release at synapses. Its unique structure and localization within the neuron underscore its importance in synaptic transmission, a fundamental process for neuronal communication and brain function.
Therapeutic significance:
Understanding the role of Synaptic vesicle membrane protein VAT-1 homolog-like could open doors to potential therapeutic strategies. Its pivotal role in neurotransmission presents an opportunity for developing treatments targeting neurological disorders, thereby enhancing brain health and function.