Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NP60
UPID:
IRPL2_HUMAN
Alternative names:
IL1RAPL-2-related protein; Interleukin-1 receptor 9; Three immunoglobulin domain-containing IL-1 receptor-related 1
Alternative UPACC:
Q9NP60; Q2M3U3; Q9NZN0
Background:
X-linked interleukin-1 receptor accessory protein-like 2, also known as IL1RAPL-2-related protein, Interleukin-1 receptor 9, and Three immunoglobulin domain-containing IL-1 receptor-related 1, plays a crucial role in the immune response. Its involvement in cellular signaling pathways underscores its importance in mediating inflammatory responses.
Therapeutic significance:
Understanding the role of X-linked interleukin-1 receptor accessory protein-like 2 could open doors to potential therapeutic strategies. Its pivotal role in immune system regulation makes it a promising target for drug discovery efforts aimed at treating inflammatory diseases.