Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NP60
UPID:
IRPL2_HUMAN
Alternative names:
IL1RAPL-2-related protein; Interleukin-1 receptor 9; Three immunoglobulin domain-containing IL-1 receptor-related 1
Alternative UPACC:
Q9NP60; Q2M3U3; Q9NZN0
Background:
X-linked interleukin-1 receptor accessory protein-like 2, also known as IL1RAPL-2-related protein, Interleukin-1 receptor 9, and Three immunoglobulin domain-containing IL-1 receptor-related 1, plays a crucial role in the immune response. Its involvement in cellular signaling pathways underscores its importance in mediating inflammatory responses.
Therapeutic significance:
Understanding the role of X-linked interleukin-1 receptor accessory protein-like 2 could open doors to potential therapeutic strategies. Its pivotal role in immune system regulation makes it a promising target for drug discovery efforts aimed at treating inflammatory diseases.